Assessment of The Protective Role of Ginger Against Paracetamol-Induced Hepatotoxicity: A Comparative Study According to the Time Period

Authors

  • Wedad Mohamed Omran Alkut Department of Biology, Faculty of Sciences, El-mergib University, El-Khoms, Libya Author
  • Njia Mild A Rajab Aser Department of Biology, Faculty of Sciences, El-mergib University, El-Khoms, Libya Author
  • Ruqayah Emran Omar Albarki Department of Biology, Faculty of Education, El-mergib University, El-Khoms, Libya Author

DOI:

https://doi.org/10.65421/jibas.v2i3.137

Keywords:

Ginger, Hipatotoxicity, Paracetamol

Abstract

Following a previous study (2013) that demonstrated ginger,s failure to protect the liver from paracetamol toxicity and its potential to exacerbate the harmful effects. This study aimed to clarify whether the duration of the dose used in the experiment affected ginger,s protective role. Male rabbits were used to study the effects of different doses of aqueous ginger extract (100,200,400)mg administered for 15 and 30 days on paracetamol-induced hepatotoxicity. The results showed that paracetamol caused liver tissue damage, elevated ALP,AST,ALT, Bilirubin levels, and decreased Albumin, total protein levels. Pre-dose of ginger for 15 days improved the physiological and histological changes. Unfortunately, pre-dose of ginger for 30 days further reduced albumin levels.

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Published

2026-07-15

Issue

Volume 2, Issue 3, 2026

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Assessment of The Protective Role of Ginger Against Paracetamol-Induced Hepatotoxicity: A Comparative Study According to the Time Period . (2026). Journal of Insights in Basic and Applied Sciences, 2(3), 127-135. https://doi.org/10.65421/jibas.v2i3.137